Vaughn made the Opening Day roster with the White Sox in 2021 and hit .235 with 15 home runs and 48 RBI. He hit 57 home runs over the next three seasons, including 21 in 2023, when he also drove in 80 runs. He struggled in the early part of 2025 and was sent to the minors before the White Sox traded him to the Brewers.

Andrew Vaughn hit a three-run homer in his first plate appearance with his new team and Freddy Peralta threw six shutout innings as Milwaukee crushed the struggling Dodgers.