Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in Nature, ...

Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in Nature, a new study demonstrates how some cancer cells use the protein ...

Interferon gamma (IFN-γ) is a cytokine that induces a series of immune responses against viruses and tumors. The pro-apoptotic, anti-tumor and anti-proliferative actions of the cells are ...

Figure 1: IFN-γ capture assay enriches tumor-reactive T cells from immunized mice. Figure 3: IFN-γ capture assay detects and enriches tumor-specific T cells from human RCC. In conclusion ...

The UAB researchers found that HIF1α-glycolysis is indispensable for IFN-γ induction in hypoxic T cells. HIF1α is a subunit of HIF, or hypoxia-inducible factor, that is known to play a crucial ...

A novel strategy using lipid nanoparticles to reprogram liver immunity shows promise in generating antitumor responses ...

Researchers derived M1 macrophages by treating M0 macrophages with proinflammatory molecules such as interferon gamma and lipopolysaccharide. Omokolade Adebowale: Wesley Ford. Jennifer Guerriero: Sam ...

Zúñiga believes that interventions that target LDHB or related metabolic pathways could be explored as a way to counteract ...

St. Jude researchers identified a protein, voltage-dependent anion channel 2 (VDAC2), that tumors use as a “signal jammer” to prevent cancer cell death and evade the immune system’s functioning.