cAMP is a vital second messenger in several signaling pathways. Interrupting the cAMP signaling pathway can aid the treatment of various human diseases.

Nevertheless, our data are in line with a large number of previous studies showing abnormalities of the cAMP signaling pathway in postmortem brains of patients with psychiatric disorders. 1,2,3,4,5,6.

Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum ...

Modulation of cAMP signaling pathway Exposure to 34.5 THz photons increased cAMP levels by 45.9% in primary neuron cultures, indicating that THz stimulation modulated neuronal growth through the ...

Dephosphorylated PTEN, a tumor suppressor gene product is able to inhibit Akt phosphorylation. Our objective was to investigate the molecular mechanism of the observed inhibition of proliferation, by ...

This information is first detected at the surface of the cell and then translated into an intracellular response by signaling molecules known as “second messengers”. A molecule called cAMP is a ...

Bear bile powder inhibits the release of NLRP3 by activating the cAMP/PKA/CREB signaling pathway to treat dextran sulfate sodium-induced colitis in mice. Xia & He Publishing Inc.

Around ten years ago, the research group identified a new and trypanosome-specific component of the cAMP signaling pathway -- the cyclic AMP response protein 3 (CARP3).

Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling. Genetics 171: 1523–1533. PubMed; ...