By creating artificial aging in mice, researchers at Lund University in Sweden have been able to track the formation of ...

Based on our experimental and simulation findings, we tentatively propose that 34.5 THz radiation increases cAMP levels by targeting AC1, thereby activating downstream signaling pathways.

This process attenuates the cAMP‒PKA signalling pathway (Rinaldi et al, 2019). Therefore, CHIP mutation may affect the intracellular alterations of cGMP/cAMP signalling pathways. To investigate the ...

Figure 4. Association of nesfatin-1 with the MC4R-cAMP signaling pathway in vitro. (A) Protein–protein interaction (PPI) network of NUCB2. (B) Bubble plot of enriched KEGG pathway statistics. The ...

Bear bile powder inhibits the release of NLRP3 by activating the cAMP/PKA/CREB signaling pathway to treat dextran sulfate sodium-induced colitis in mice Xia & He Publishing Inc.

Many of these inputs form synapses onto indirect and direct-pathway projection medium spiny neurons (MSN). Both subpopulation of MSNs contains GPCRs that can oppositely regulate the cAMP-PKA signaling ...

When cAMP is used as a second messenger, it helps the cell fire a greater signal, otherwise known as an action potential, with specific circumstances. He affirms “After 50 years of research, the ...

Around ten years ago, the research group identified a new and trypanosome-specific component of the cAMP signaling pathway -- the cyclic AMP response protein 3 (CARP3).

The central role of latrophilins as postsynaptic adhesion-GPCRs in synapse formation raises the question whether latrophilins actually function as GPCRs in synapse formation. An intrinsic GPCR ...

Finally, the activation of PKA signaling pathways implicated in pain is also possible through the use of drugs such as 8-BromocAMP or cAMPS-Sp, which, in effect, are membrane-permeable cAMP ...

cAMP is a vital second messenger in several signaling pathways. Interrupting the cAMP signaling pathway can aid the treatment of various human diseases.