Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's ...

By creating artificial aging in mice, researchers at Lund University in Sweden have been able to track the formation of ...

Based on our experimental and simulation findings, we tentatively propose that 34.5 THz radiation increases cAMP levels by targeting AC1, thereby activating downstream signaling pathways.

This process attenuates the cAMP‒PKA signalling pathway (Rinaldi et al, 2019). Therefore, CHIP mutation may affect the intracellular alterations of cGMP/cAMP signalling pathways. To investigate the ...

Figure 4. Association of nesfatin-1 with the MC4R-cAMP signaling pathway in vitro. (A) Protein–protein interaction (PPI) network of NUCB2. (B) Bubble plot of enriched KEGG pathway statistics. The ...

Bear bile powder inhibits the release of NLRP3 by activating the cAMP/PKA/CREB signaling pathway to treat dextran sulfate sodium-induced colitis in mice Xia & He Publishing Inc.

Many of these inputs form synapses onto indirect and direct-pathway projection medium spiny neurons (MSN). Both subpopulation of MSNs contains GPCRs that can oppositely regulate the cAMP-PKA signaling ...

When cAMP is used as a second messenger, it helps the cell fire a greater signal, otherwise known as an action potential, with specific circumstances. He affirms “After 50 years of research, the ...

In addition, more signaling factors have been identified in both CBF-mediated and non-CBF-mediated signaling pathways, and these newly identified signaling factors play key or essential roles in other ...

Around ten years ago, the research group identified a new and trypanosome-specific component of the cAMP signaling pathway -- the cyclic AMP response protein 3 (CARP3).

Hence, the molecular details and dynamics of cAMP-signaling pathways in primary cilia remain largely unknown. Optogenetics might be the key to overcome this issue, not least because it has proven to ...