1 day ago · One of the medicines, naltrexone, has shown a small effect size on alcohol-use disorder, Hendershot told CNN. The semaglutide trial showed effect sizes “in the medium to large range,” he said ...

1 day ago · The findings, published in JAMA Psychiatry, showed that weekly injections of semaglutide – compared with placebo injections – reduced alcohol craving, drinking quantity and the frequency of heavy drinking days in adults with symptoms of alcohol use disorder. Results also showed that after treatment, those in the semaglutide group consumed ...

1 day ago · Results, measured by grams of alcohol consumed and breath alcohol concentration, indicated that semaglutide injections reduced weekly alcohol craving, reduced average drinks on drinking days and led to greater reductions in heavy drinking days, relative to the placebo. A key finding was that the magnitude of semaglutide’s effects on several ...

1 day ago · It is the first randomized controlled trial on semaglutide and alcohol consumption. The study followed 48 adults who met criteria for alcohol use disorder, a condition often characterized by ...

1 day ago · A lab visit with their favorite alcohol was repeated at the end of the study. During the last weeks of the study, nearly 40% in the semaglutide group reported no heavy drinking days compared with 20% in the placebo group. And in the final lab test, the semaglutide group drank roughly half the amount, on average, compared to those who got the ...

Mar 13, 2024 · In the current study, the researchers demonstrated that semaglutide reduced binge-like alcohol drinking in both male and female mice, and that the effect was dose-dependent (i.e., greater amounts of semaglutide led to greater reductions in binge alcohol intake).

2 days ago · Simmons is the director of OSU’s Biomedical Imaging Center and lead investigator on the Semaglutide Therapy for Alcohol Reduction — Tulsa, or STAR-T, clinical trial.He also published one of ...

1 day ago · Objective To evaluate the effects of once-weekly subcutaneous semaglutide on alcohol consumption and craving in adults with alcohol use disorder (AUD). Design, Setting, and Participants This was a phase 2, double-blind, randomized, parallel-arm trial involving 9 weeks of outpatient treatment. Enrollment occurred at an academic medical center in ...

May 4, 2023 · Though alcohol may not interact with Ozempic, taking semaglutide while drinking alcohol may increase the risk of low blood glucose. Alcohol may also counteract some of Ozempic’s potential benefits.

Meaning GLP-1 agonists, especially semaglutide, offer promise as a novel treatment to reduce alcohol consumption and to prevent development of alcohol-related outcomes, but randomized clinical trials are needed to verify these initial findings.